Basic Information
VIS ID
TVIS10007927
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1791
Orient
-
Integrated sequence
CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
79795887/81838011 (Hg38)
End
79795887/81838011 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/144142; hsa-mir-4525/Downstream/398657;
Nearest TSS
ENST00000595228/Upstream/2961; ENST00000576784/Downstream/5154;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/4198, chr17-CpG: 25/Downstream/3399
Nearby gene
PPP1R27(-2961) ; P4HB(+5147) ;
Upstream sequence
catcctgtttccaaacaacggtcacattctgaggtcttgagggctaggacttcaacgttaattaaggagacacatgagtcaacccataaTGCTGGTAAAA
Downstream sequence
CCCTGCAGGTGGTCACTAAAGGCCTGAATGAGGACAGAACCAAGACTGGCCAGCAGCTCTTTGCAGGGGCAGAGGAGAGCTGGGCCACCAACAGCCTCGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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