Basic Information
VIS ID
TVIS10007928
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1890
Orient
+
Integrated sequence
ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG| |TGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATC
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
79795901/81838025 (Hg38)
End
79795901/81838025 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/144156; hsa-mir-4525/Downstream/398643;
Nearest TSS
ENST00000595228/Upstream/2975; ENST00000576784/Downstream/5140;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/4212, chr17-CpG: 25/Downstream/3385
Nearby gene
PPP1R27(-2975) ; P4HB(+5133) ;
Upstream sequence
acaacggtcacattctgaggtcttgagggctaggacttcaacgttaattaaggagacacatgagtcaacccataaTGCTGGTAAAACCCTGCAGGTGGTC
Downstream sequence
ACTAAAGGCCTGAATGAGGACAGAACCAAGACTGGCCAGCAGCTCTTTGCAGGGGCAGAGGAGAGCTGGGCCACCAACAGCCTCGCATCATTAGGCTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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