Basic Information
VIS ID
TVIS10007932
Fusion event
HBV-ZNF137P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
19
Orient
+
Integrated sequence
AATTCCACAACCTTCCACC| |AAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATC
Host Sequence
Chromosome
chr19
Cytoband
q13.41
Reference genome
GRCh37/hg19
Start
53103255/52600002 (Hg38)
End
53103255/52600002 (Hg38)
Orient
-
Location type
ncRNA_exonic
Fragile sites / regions
FRA19A
Target gene
ZNF137P
Nearest miRNA
hsa-let-7e/Upstream/318109; hsa-mir-10394/Downstream/1066677;
Nearest TSS
ENST00000633603/Upstream/14441; ENST00000594546/Downstream/18038;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/14595, chr19-CpG: 44/Downstream/1291
Upstream sequence
gacgctagttagctgacacagatggtcacctccattaccaagtagagtcaggatgaactatgtgtgactgttcaactatgtgtcctcttccctgaggact
Downstream sequence
gattagtgtttatcttgaaaacatgtccttaatgggttgtatagaacactgaagcatctgatttcaaactcttagctcttttcctctatttcccatcaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate