VISDB Viral Integration Site DataBase

VIS ID

TVIS10007933

Fusion event

HBV-ZNF83 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1906

Orient

-

Integrated sequence

ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG| |ACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTC

Chromosome

chr19

Cytoband

q13.41

Reference genome

Start

End

53152227/52648974 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-155-5p ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-329-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-4452 ; hsa-mir-6844 ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-510-3p ; hsa-mir-488-3p ; hsa-mir-1257 ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4302 ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-4752 ; hsa-mir-3911 ; hsa-mir-8056 ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-4320 ; hsa-mir-1825 ; hsa-mir-664a-3p ; hsa-mir-4729 ; hsa-mir-29b-2-5p ; hsa-mir-584-5p ; hsa-mir-3193 ; hsa-mir-1539 ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-8076

Nearest miRNA

hsa-let-7e/Upstream/367081; hsa-mir-10394/Downstream/1017705;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/10414, chr19-CpG: 59/Downstream/40912

Upstream sequence

acacaccagaagctgactagtctatgcatggctgaagcttgaaactccaggccctacCTCCACCTCCACCCTCTAACCAGGCCCAGCTTCCAAAGCAGCC

Downstream sequence

TCCACCCTCTTGCCCAGCTCCAGCGACAGTTTTCATGCCCTGCCCCCTCAACGACCTTTCCCTTCTCCCGCCGGGTCCCCACCCACTGTCCAGAACCCAC