Basic Information
VIS ID
TVIS10007934
Fusion event
HBV-LOC105373521 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2023
Orient
+
Integrated sequence
GAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAG| |CCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGT
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
104713707/104097249 (Hg38)
End
104713707/104097249 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105373521
Nearest miRNA
hsa-mir-1285-2/Upstream/1664883; hsa-mir-10b/Downstream/5044241;
Nearest TSS
ENST00000437798/Upstream/43747; ENST00000416008/Downstream/49980;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1360294, chr2-CpG: 44/Downstream/561881
Nearby gene
TMEM182(-1279569) ; LOC100287010(+281601) ;
Upstream sequence
ttcagtgccttttgcatacatctcagttggaaaataagtcaacagctttatttatatataggcacttttgttttctcagccatagcatgttaaagcttat
Downstream sequence
tgctctgcaggaaagtatagaaatcaggtattcttccaataatgaatattcgtctaacaaatattaaatttatgtcctgctggtttatatctgtgcattt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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