DGUOK _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007939
Fusion event
HBV-DGUOK integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1849
Orient
+
Integrated sequence
GGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTT| |GTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACT
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
74184935/73957808 (Hg38)
End
74184935/73957808 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
DGUOK
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-297
Nearest miRNA
hsa-mir-1285-2/Upstream/3704803; hsa-mir-10b/Downstream/1133004;
Nearest TSS
ENST00000437798/Upstream/30900; ENST00000441217/Downstream/23553;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/30654, chr2-CpG: 171/Downstream/26279
Upstream sequence
GGGCCTTTTTATTAGATTGTATTTCTCCAGCTTTTTCTTTGTTTCTTAACATTTCCCTAGACTGAACATTGTGATTGATGGTGATAGTTGGCTCAGCATG
Downstream sequence
AAGGGCTGAAAATGTTAGAGAAATTGTCAGTATTACTAAGTTGGCATTCCTGGTTTCTGCCTGTCCTCCCTTTAGGCTTGGTTTGTTGTCCACTTAAAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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