Basic Information
VIS ID
TVIS10007941
Fusion event
HBV-LINC02246 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1834
Orient
+
Integrated sequence
GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGC
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
16222344/14850023 (Hg38)
End
16222344/14850023 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
LINC02246
Nearest miRNA
hsa-mir-10396a/Upstream/1125749; hsa-let-7c/Downstream/1689066;
Nearest TSS
ENST00000624081/Upstream/16367; ENST00000430391/Downstream/31887;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/466258, chr21-CpG: 171/Downstream/214152
Nearby gene
LOC388813(-206916) ; NRIP1(+111212) ;
Upstream sequence
tacaggcatgcaccaccatgcctggataattttgtgtttttagtagagacagggtttctccatgttggtcgggctggtctcgaactcccaacttcagatg
Downstream sequence
atccaactaccttggcctcctaaagtgctgacattacaggcatgagccaccgcacccagccactgaactcattttaaactggcttctcctttacaactac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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