Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007944
Fusion event
HBV-ACOX2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
Start
End
58501502/58515775 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/2663181; hsa-mir-12124/Downstream/2102030;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/23228, chr3-CpG: 47/Downstream/70987
Upstream sequence
TATTTTTTAGGTATTCATTTTTTGAATAGGTAATATACACATGCACAGGATTAAATTCCAAAAGGGTATAGGCACCATATGATGATGTCAACCTCTCTCA
Downstream sequence
ttcttttctttcctttttttgagacaaggtctcactttgttgcccaggctggagtgcagtggtgtgatcatagcttactgcaacctcaacctcctgggat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.