Basic Information
VIS ID
TVIS10007947
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2613
Orient
+
Integrated sequence
TCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAA| |TGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAA
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
173992252/173071101 (Hg38)
End
173992252/173071101 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1884809; hsa-mir-1305/Downstream/197059;
Nearest TSS
ENST00000502981/Upstream/261741; ENST00000502407/Downstream/97652;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1257134, chr4-CpG: 154/Downstream/97691
Nearby gene
GALNTL6(-30694) ; GALNT7(+97652) ;
Upstream sequence
gactacagttggatgtcagagagaagcagtttgactttagagggacagcttgatggcatggcttcggagaggagtctggccagggacagccagactccag
Downstream sequence
gggggcacaggtgctagcctagagagtagggctacagggaacaatctgacactaggcagacctggatcttgaggccaggggtgctaaactggcagtgggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate