hsa-mir-3202 _LIHC.png
hsa-mir-4742-3p _LIHC.png
hsa-mir-4434 _LIHC.png
FSTL4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007954
Fusion event
HBV-FSTL4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
132731060/133395368 (Hg38)
End
132731060/133395368 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
FSTL4
miRNAs that regulate target gene
hsa-mir-3691-5p ; hsa-mir-432-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-1193 ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4472 ; hsa-mir-3175 ; hsa-mir-4447 ; hsa-mir-6878-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-7515 ; hsa-mir-194-3p ; hsa-mir-1296-3p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-4662b ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4742-3p ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-7856-5p ; hsa-mir-4503 ; hsa-mir-6792-5p
Nearest miRNA
hsa-mir-10397/Upstream/1029769; hsa-mir-103a-1/Downstream/32228;
Nearest TSS
ENST00000502646/Upstream/7595; ENST00000513561/Downstream/188273;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/342691, chr5-CpG: 192/Downstream/215685
Upstream sequence
tttgaaagggatttctatcattctggctgttgtgtggagcagagactgtaggggacaaaagtggcagcagggagaccagttaggaggcactgcagtcttc
Downstream sequence
ccgcagcttcactcctgaagccagcgagaccacgaacccaccagaaggaagaaactctgaacacgtccaaacatcagaaggaacaaactccggacacacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate