Basic Information
VIS ID
TVIS10007961
Fusion event
HBV-LOC101929307 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
106
Orient
-
Integrated sequence
ACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTG| |CCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGC
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
8793594/8793482 (Hg38)
End
8793594/8793482 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101929307
Nearest miRNA
hsa-mir-4277/Upstream/332483; hsa-mir-10397/Downstream/260334;
Nearest TSS
ENST00000502646/Upstream/8014; ENST00000506655/Downstream/46250;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/335322, chr5-CpG: 138/Downstream/751098
Nearby gene
MIR4458HG(-330385) ; SEMA5A(+241544) ;
Upstream sequence
ccttttttcctttttataaattatgcagtctgtggtattcttttatagaagcatgaaatggacaaagacTCCATTTTCAAGAGCAAGCACTTTTGTAGTT
Downstream sequence
tcgtgtgactccctttagtgggttgaccccttggagaggaccccagttacaaagtctgtggggagttctatcatagtacagtattgattttggaggaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate