Basic Information
VIS ID
TVIS10007966
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1762
Orient
-
Integrated sequence
GACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTA| |AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC
Host Sequence
Chromosome
chr6
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
133461527/133140388 (Hg38)
End
133461527/133140388 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/1025125; hsa-mir-1202/Downstream/1838950;
Nearest TSS
ENST00000381078/Upstream/52260; ENST00000441015/Downstream/100210;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/325698, chr6-CpG: 138/Downstream/100560
Nearby gene
LINC00326(-33810) ; EYA4(+100968) ;
Nearest cancer related gene
EYA4(TSG, +100968) ;
Upstream sequence
ggaggcagggaagaagggagagagggagggagggcgggaaggagggaaggaaggaaggaaaaaattagctgggcatggtggtgtgcacctgtagtcccag
Downstream sequence
AATGTTTTTCACCATAAAATTCTGTCAGAGAAACAAGAAGTCCCTGAAATATACTTTTATTTGTGCATTAAAGGATAGATTGGAAGTTTTAAGGAGAAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate