Basic Information
VIS ID
TVIS10007967
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2340
Orient
+
Integrated sequence
AACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACT| |ACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGG
Host Sequence
Chromosome
chr6
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
133461574/133140435 (Hg38)
End
133461574/133140435 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/1025172; hsa-mir-1202/Downstream/1838903;
Nearest TSS
ENST00000381078/Upstream/52307; ENST00000441015/Downstream/100163;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/325745, chr6-CpG: 138/Downstream/100513
Nearby gene
LINC00326(-33857) ; EYA4(+100921) ;
Nearest cancer related gene
EYA4(TSG, +100921) ;
Upstream sequence
GCAAATGTGTAAATTTAGTAAAGTCGACGGGGGTGAACATTTAAGCAGTTCTTTTTCATTTTTTTAAAAATTGTGTTTTTACTACAAATAGCAAAATACA
Downstream sequence
AATATACTTTTATTTGTGCATTAAAGGATAGATTGGAAGTTTTAAGGAGAAATTGCAAGGCTTAATTCAGGTAGTTTTTTTTTTTTAAATACAGGCAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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