Basic Information
VIS ID
TVIS10007968
Fusion event
HBV-MTFR2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1713
Orient
-
Integrated sequence
AGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAA| |AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
136571806/136250668 (Hg38)
End
136571806/136250668 (Hg38)
Orient
-
Location type
upstream
Target gene
MTFR2
miRNAs that regulate target gene
hsa-mir-193b-3p
Nearest miRNA
hsa-mir-10398/Upstream/1011412; hsa-mir-1202/Downstream/2184545;
Nearest TSS
ENST00000381078/Upstream/333; ENST00000607749/Downstream/17654;
Nearest CpG islands
chr6-CpG: 51/Target, None/Upstream, None/Downstream
Upstream sequence
tcaaaaattccttcagttctaatagcttataaGTGTTGCTCttttgtttttgttttcgttttttattttgggacagagtttcgctcttgtcacccaggct
Downstream sequence
AAATCGCGATTTATTTTTTGGTCATTTCATTTGTTCAGCTAATATTAAAATACTTGTGGAACTGGCAGAAGCCAAGCACTACCCCCGAGGGTTTTGCAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate