Basic Information
VIS ID
TVIS10007970
Fusion event
HBV-LOC101929555 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1832
Orient
+
Integrated sequence
TGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT| |CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
40878124/40910385 (Hg38)
End
40878124/40910385 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
LOC101929555
Nearest miRNA
hsa-mir-1236/Upstream/1836004; hsa-mir-10398/Downstream/688338;
Nearest TSS
ENST00000381078/Upstream/195022; ENST00000470917/Downstream/122602;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/310544, chr6-CpG: 39/Downstream/117678
Nearby gene
LRFN2(-322998) ; UNC5CL(+116516) ;
Upstream sequence
ATATAAATGTGATCATTCCCTTCTCTGTTCTCTGGATCCATATCCATGGTCATCCTCACCAGGCAGTGAGGTATGttgcttgtatgtctctactgtatca
Downstream sequence
AGAATCTCTTTATAGAGTCACTTCCAGCCTTTCTCATTTCAGTGGATGACACAACATCTAAGCTCCAGTTattggtcttagtgaatcagggctaccctat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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