Basic Information
VIS ID
TVIS10007985
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chrX
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
26542623/26524506 (Hg38)
End
26542623/26524506 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/6507319; hsa-let-7f-2/Downstream/1971049;
Nearest TSS
ENST00000429181/Upstream/308337; ENST00000569334/Downstream/33831;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1501261, chrX-CpG: 30/Downstream/33135
Nearby gene
MAGEB6(-328860) ; VENTXP1(+33831) ;
Upstream sequence
ttagggttagggttagggttagggttagggtgagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttag
Downstream sequence
TTTTTTATTTTTCATAAAATATGAGCTTTGTTAATCTTAGAATTAGAGCATATTTTATTCAAAATGTCTAGGGTGAGCTCAATGCACTAACACAAATATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate