VISDB Viral Integration Site DataBase

VIS ID

TVIS10007991

Fusion event

HBV-PDE3A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

26

Orient

+

Integrated sequence

AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC

Chromosome

chr12

Cytoband

p12.2

Reference genome

Start

End

20691684/20538750 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-128-3p ; hsa-mir-211-5p ; hsa-mir-3680-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-3915 ; hsa-mir-1224-5p ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-3928-3p ; hsa-mir-5582-3p ; hsa-mir-8055 ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-1304-5p ; hsa-mir-4677-5p ; hsa-mir-192-3p ; hsa-mir-2116-5p ; hsa-mir-22-5p ; hsa-mir-3613-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-8485 ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-7843-3p ; hsa-mir-5585-5p ; hsa-mir-3191-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-942-5p ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-3128 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-6814-5p ; hsa-mir-3614-3p ; hsa-mir-7849-3p ; hsa-mir-6818-3p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-377-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6846-3p ; hsa-mir-4743-3p ; hsa-mir-6888-3p ; hsa-mir-3182 ; hsa-mir-3120-5p ; hsa-mir-1237-3p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-361-5p ; hsa-mir-3171 ; hsa-mir-2115-3p ; hsa-mir-1265 ; hsa-mir-5692a ; hsa-mir-106a-3p ; hsa-mir-6844 ; hsa-mir-4684-3p ; hsa-mir-103a-2-5p ; hsa-mir-8066 ; hsa-mir-1267 ; hsa-mir-3147 ; hsa-mir-367-5p ; hsa-mir-4328 ; hsa-mir-4425 ; hsa-mir-450a-1-3p ; hsa-mir-4652-3p ; hsa-mir-4747-5p ; hsa-mir-5196-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/2865356; hsa-let-7i/Downstream/3673671;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/168562, chr12-CpG: 97/Downstream/12841

Upstream sequence

AGAGTGAAGAGCTAAAAATTCTTTACTACTTGTGTATTCAACAGTAGAATTTTAAAAATCAACTCcttattgtagcctaaaccacctgggttcaagcaat

Downstream sequence

cctcctgcctcagcctcccaaatagctgggactataggtgtgtgtcatcaggcctggctaatttctaaaattttttgtagacgtgagatcccactacatt