Basic Information
VIS ID
TVIS10008008
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
438
Orient
+
Integrated sequence
ACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTG| |TTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTG
Host Sequence
Chromosome
chr22
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
16598657/15379304 (Hg38)
End
16598657/15379304 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-3/Downstream/2384876;
Nearest TSS
ENST00000624155/Upstream/74748; ENST00000252835/Downstream/148855;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/2563670, chr22-CpG: 65/Downstream/131499
Nearby gene
OR11H1(-148853) ; CCT8L2(+472991) ;
Upstream sequence
ataggattacagaacacttctacgagtgtttgaatgtttgtccctcagacaggattctggaacacagtggctgggttctgagtgtttgtcccttgcatag
Downstream sequence
gattccaaaacactgctgctgggctctgagtgtttgtcactcacataggattccagaacccagctgctggattctgagtgcttgtcactcagatacgatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate