Basic Information
VIS ID
TVIS10008025
Fusion event
HBV-LOC105373277 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
248687850/248524549 (Hg38)
End
248687850/248524549 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
LOC105373277
Nearest miRNA
hsa-mir-101-1/Upstream/1322489; hsa-mir-3124/Downstream/301828;
Nearest TSS
ENST00000473358/Upstream/2934; ENST00000438623/Downstream/24207;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/587125, chr1-CpG: 49/Downstream/167180
Nearby gene
OR2G6(-1952) ; OR2T29(+33995) ;
Upstream sequence
AGTAGAGAAGTAGTTCTACAGGAAGCGTCACATGTACAAATGCATTATTCCTGATAACCCGAGCAACACAGCATAGGAAAGAATGTACCTGTGTCAGAGT
Downstream sequence
CTCAATCAATTTACATGGAATATGGCCCCAGGGCAAAAGATGTGGCATTTAAAGGAAAGAAATAGCTCCAGGTGAAAAGACAACCATGTGTAAAGCAATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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