Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008026
Fusion event
HBV-ABCD3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2432
Orient
+
Integrated sequence
CGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCA| |ATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAA
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
Start
End
94983359/94517803 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-101-1/Upstream/670892; hsa-mir-11399/Downstream/25899;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/98957, chr1-CpG: 93/Downstream/23478
Upstream sequence
TTGACTCCAGGAAAAGCCATTTTGGTTTTCCTTAACTAAATGATAAATGTACCCCTCTCAGTCTGCAGTATTGAGTTGTTTAAAGTATATGTGCAGTCTT
Downstream sequence
GCTTACAAGGAGGGGTTACCATGTATCACACCTAATCTTCCCAATGTTTGGGATATTAAAACACAAAGTCCTTAACATGCCAGGCTCAAGGTCTTATAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.