Basic Information
VIS ID
TVIS10008035
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
32437416/32426095 (Hg38)
End
32437416/32426095 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/1532110; hsa-mir-11401/Downstream/1737483;
Nearest TSS
ENST00000527434/Upstream/160581; ENST00000568972/Downstream/32663;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/76935, chr16-CpG: 36/Downstream/52373
Nearby gene
LOC390705(-136114) ; TP53TG3B(+247433) ;
Upstream sequence
CTCCAATGCCTACTCTGTATTTAAAACTGAGCACAGCAGTGATTGATACAGGTCAATGGCTTTGATTAAAGTCTCTGCTTCCTGATTTGGCAAATAAGGA
Downstream sequence
ATGTCAAAAAATATACTTGATGCAGAGTATCCCTCTGAATTATACTTTCCCTTTCTCTACTAAATTGCCTATTGATGTTTGATAATTTCCCCTTAAACAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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