Basic Information
VIS ID
TVIS10008037
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1722
Orient
-
Integrated sequence
TGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTT| |GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
79900640/79866743 (Hg38)
End
79900640/79866743 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA16D
Nearest miRNA
hsa-mir-1225/Upstream/2997724; hsa-mir-11401/Downstream/1518275;
Nearest TSS
ENST00000527434/Upstream/39593; ENST00000565531/Downstream/173919;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/265103, chr16-CpG: 42/Downstream/674101
Nearby gene
MAF(-266018) ; DYNLRB2(+674214) ;
Nearest cancer related gene
MAF(OG, -266018) ;
Upstream sequence
tctgcattttcaataaacacttcagagaattctaatgcagaaaatccatgcgtagaacacatttttagAACACTTAGCTGTTATGACACATTGTCTATCA
Downstream sequence
GGATTATGTTAAATGGTGGCAAGCCTTTAGAATTAAAGAAACTTTCTATTGACTGGTATCAGGAAACTTGATAATTTTTATTACTGATAATaatgatagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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