Basic Information
VIS ID
TVIS10008038
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1811
Orient
-
Integrated sequence
AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
86175999/86142393 (Hg38)
End
86175999/86142393 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12128/Upstream/223977; hsa-mir-11401/Downstream/1692199;
Nearest TSS
ENST00000527434/Upstream/52867; ENST00000601250/Downstream/16405;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/168312, chr16-CpG: 71/Downstream/144176
Nearby gene
IRF8(-219788) ; LINC02135(+144038) ;
Nearest cancer related gene
IRF8(TSG, -219788) ;
Upstream sequence
aagaaaagatttggacacagagacacacacagagggaagacagccatgtgaaaacggaggcaagaattgcaaagacgcagctgcagcccaagaacaccaa
Downstream sequence
gggttgtaggctgaaccaggagctggaagaggcaaggaagccttcttgagccttcagaaggagtgaggcactgctggcaccttgattttgaatttcggga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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