Basic Information
VIS ID
TVIS10008041
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1816
Orient
-
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
21989716/22490387 (Hg38)
End
21989716/22490387 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/3145813; hsa-mir-10226/Downstream/4803523;
Nearest TSS
ENST00000595228/Upstream/70365; ENST00000540040/Downstream/32724;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/35426, chr17-CpG: 30/Downstream/27056
Nearby gene
FLJ36000(-76646) ; MTRNR2L1(+32721) ;
Upstream sequence
ACCTGAGAGGGGCTGTGAGGCTCTGAGCAGGAGAGAGACTTGCCCAAAGGCCAAAGACAGGGAGGAGTAGAGTCTAACATGAGTACAAGATTGACTAGGA
Downstream sequence
CCATCGTTTATCTCTTTACACAGGAACAGGAGGAACTTGAGGCAAGGAAGGGCTATATAAGATGCAGTCCCCTCCCTGCAGGGGCCAGCTTGGTGCTGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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