Basic Information
VIS ID
TVIS10008043
Fusion event
HBV-KRT18P55 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1878
Orient
+
Integrated sequence
GAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAG| |CTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTT
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
26632785/28305759 (Hg38)
End
26632785/28305759 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
KRT18P55
Nearest miRNA
hsa-mir-1180/Upstream/1011763; hsa-mir-10226/Downstream/54895;
Nearest TSS
ENST00000595228/Upstream/39390; ENST00000582113/Downstream/13336;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/54103, chr17-CpG: 53/Downstream/1109
Upstream sequence
accccccaaagtgctgcaatacaggcatgagccactgcacccagccCTTAACTGTTTCTAATGGAACTTAAAATTTTTTTTTCCATATTCTACTTATGTA
Downstream sequence
GGAACATTTCATACATAATTATGTTGCTCAGGAAAGGTGAATCTATAAAGGATCAAAATACATTTTACTCCTTTATTCAATTCACAAAATGCTAAACTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate