Basic Information
VIS ID
TVIS10008044
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
34897837/36541988 (Hg38)
End
34897837/36541988 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/4191786; hsa-mir-10226/Downstream/491757;
Nearest TSS
ENST00000595228/Upstream/6433; ENST00000611219/Downstream/255;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/6356, chr17-CpG: 107/Downstream/2313
Nearby gene
PIGW(-2687) ; GGNBP2(+2900) ;
Nearest cancer related gene
GGNBP2(TSG, +2900) ;
Upstream sequence
CTACTCTAAAACCAGGAAGATGCACAGTGAAAACTTTGAAAAATTATTTTGCCATGAAATAATTTTCTAAGCGTTTTCCTTGGGAtattgattttattgt
Downstream sequence
atcgattgtattatattgtatggtattagattagattagattggattggattTATAGCACCCAGGCTACCTCCTTGAGAAACAGCAACTTACCTAGCAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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