Basic Information
VIS ID
TVIS10008048
Fusion event
HBV-LOC105373848 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
-
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
206964475/206099751 (Hg38)
End
206964475/206099751 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
LOC105373848
Nearest miRNA
hsa-mir-10b/Upstream/16966640; hsa-mir-1244-1/Downstream/683483;
Nearest TSS
ENST00000437798/Upstream/13448; ENST00000453039/Downstream/15796;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/13947, chr2-CpG: 94/Downstream/59435
Nearby gene
INO80D(-13569) ; GCSHP3(+15822) ;
Upstream sequence
AAAAACAAGTACTAGCAAGTGAATTGCTTAAGATTACATAGACTAGCCCAATTCTAGAGAGAAATAATTCAAGTGTATCTTATTGTCATCTTGTTGTTaa
Downstream sequence
gtacagacatattcagatttcaccagtttcccactaatgttctttttcttttttcttttctttttttgagacaggttctcactctgttgccaagctggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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