Basic Information
VIS ID
TVIS10008051
Fusion event
HBV-ARHGEF38-IT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
106483601/105562444 (Hg38)
End
106483601/105562444 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
ARHGEF38-IT1
Nearest miRNA
hsa-mir-12113/Upstream/4232030; hsa-mir-1243/Downstream/3926254;
Nearest TSS
ENST00000502981/Upstream/9551; ENST00000508036/Downstream/70266;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/88279, chr4-CpG: 58/Downstream/145974
Upstream sequence
agtcagcagccatgtgtgaagtctagttacctagagcccactgtgctatgaggaagtccaaattagtctcatggaaaggccatgtTGGAAGAGAAAGAGA
Downstream sequence
GTCATTTTCACTTACCCACTATGTAATGGTAGTTAACTTTCAGTTAATTTCTTTACATTCTTTTTCTGTAAAGAAAGattataaataaataaatttaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate