Basic Information
VIS ID
TVIS10008055
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1857
Orient
+
Integrated sequence
GGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGT| |CCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64118306/63252588 (Hg38)
End
64118306/63252588 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2329904; hsa-mir-1243/Downstream/3024236;
Nearest TSS
ENST00000502981/Upstream/124277; ENST00000509473/Downstream/241690;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2049505, chr4-CpG: 60/Downstream/96541
Nearby gene
LPHN3(-1180138) ; TECRL(+1025871) ;
Upstream sequence
GGTCACACAGCgtctactcttaagcagcacctttgcagaggagaccctgcctcctctcctacctacagtccaccctgctgccagcctacttcacctgtaa
Downstream sequence
TTTGCTTAGTGTAGAAGACAATTGTTTTTCTAATTAATATAGTTACTATTTCTTGAGATTATTTTCTTTAGAGTCGTTAGAAGTAGACTTTCTTGTGTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate