Basic Information
VIS ID
TVIS10008059
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2177
Orient
+
Integrated sequence
TTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAA| |TATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGG
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
End
180893531/181466530 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/243897;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/14929, None/Downstream
Nearby gene
OR4F16(-98305) ;
Upstream sequence
ccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccct
Downstream sequence
TGCTCATCATCATAGCGTGCCATAACATATAGTAAGATTTGGGTTTGTTTCTGGGGAGAGATCTTGGTATAGAGAAAGGAGAAATGCTTAGAGCCACCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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