Basic Information
VIS ID
TVIS10008061
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
-
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr6
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
126850915/126529769 (Hg38)
End
126850915/126529769 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/45056; hsa-mir-1202/Downstream/5262403;
Nearest TSS
ENST00000381078/Upstream/189595; ENST00000485757/Downstream/588835;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/189528, chr6-CpG: 30/Downstream/113734
Nearby gene
CENPW(-181161) ; RSPO3(+589133) ;
Nearest cancer related gene
CENPW(OG, -181161) ;
Upstream sequence
cagcCAGAACATCCAGTTCTATCAATTCCGCATCAGAATTTCTCCCAAATCTGGATCTCTTAAATTGGCCTTCAACATCATTTCCTTGCTGAAGCAAAGC
Downstream sequence
CCACTGTACAGCAGAGTGTGCTAGAATGATTAGAACCAAACTACACAGTAAGCTGAGGTCTGTGATAATGTAGTAAGCAAGGAAATAAAAAGAGACAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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