Basic Information
VIS ID
TVIS10008068
Fusion event
HBV-EGFR-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
-
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55254823/55187130 (Hg38)
End
55254823/55187130 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA7A
Target gene
EGFR-AS1
Nearest miRNA
hsa-mir-1183/Upstream/10305330; hsa-mir-10399/Downstream/1768655;
Nearest TSS
ENST00000635602/Upstream/34793; ENST00000485503/Downstream/1804;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/166718, chr7-CpG: 120/Downstream/67339
Upstream sequence
ATGGGAGGAAGCAGCCTGGGAGGCTGGGGAGGGGTCATGTTGATGCATAAATATTTTAATTGCATCATTACTTTGAACCTTTGATACCTCTTTtctgtgc
Downstream sequence
TGGGGAGGAGGGGTGGACCCCTCAGGGCCAAGCACATGGAGCCTCATCACAAAGGCAAGATGGTGGCCAAATTCAAGGTCGCTGCAAAAGGAATGGAGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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