VISDB Viral Integration Site DataBase

VIS ID

TVIS10008069

Fusion event

HBV-NSD3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2252

Orient

+

Integrated sequence

TAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGA| |GTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGA

Chromosome

chr8

Cytoband

p11.23

Reference genome

Start

End

38157346/38299828 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-10b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-203a-3p ; hsa-mir-526b-5p ; hsa-mir-4635

Nearest miRNA

hsa-mir-124-1/Upstream/8342480; hsa-mir-10400/Downstream/2971220;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/30314, chr8-CpG: 160/Downstream/81843

Nearest cancer related gene

NSD3(OG, No orient, 0)

Upstream sequence

ggcttatgcctgtaatcccagcactttggaaggccgaggcaggcggatcacctgaggtcaggagttcgagaccagcctgaccaacatggagaaaccccat

Downstream sequence

ACTTCAAATAATTTGAAGATATAAACACTTGACATCATACAGAAAACCCCTTAGGGAAAACAAAGCTACACTGCTTCGTATTTGGATGTACAATGACGAC