VISDB Viral Integration Site DataBase

VIS ID

TVIS10008070

Fusion event

HBV-NSD3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1756

Orient

-

Integrated sequence

TAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATT| |AGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATG

Chromosome

chr8

Cytoband

p11.23

Reference genome

Start

End

38157354/38299836 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-10b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-203a-3p ; hsa-mir-526b-5p ; hsa-mir-4635

Nearest miRNA

hsa-mir-124-1/Upstream/8342488; hsa-mir-10400/Downstream/2971212;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/30322, chr8-CpG: 160/Downstream/81835

Nearest cancer related gene

NSD3(OG, No orient, 0)

Upstream sequence

tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg

Downstream sequence

TAATTTGAAGATATAAACACTTGACATCATACAGAAAACCCCTTAGGGAAAACAAAGCTACACTGCTTCGTATTTGGATGTACAATGACGACAGCCCAAA