Basic Information
VIS ID
TVIS10008085
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
60556154/60090482 (Hg38)
End
60556154/60090482 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1B
Nearest miRNA
hsa-mir-12136/Upstream/357186; hsa-mir-101-1/Downstream/1755593;
Nearest TSS
ENST00000473358/Upstream/16712; ENST00000456878/Downstream/24393;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16614, chr1-CpG: 86/Downstream/952488
Nearby gene
C1orf87(-16712) ; NFIA(+986792) ;
Upstream sequence
TAATAACTCTTAATCCTCTGCTATATGCCCAACACTATATTAGGTGTTTTTACAGATTGGTGTTAATCTTCAAATCTAAGCAATTCAAATGTaactagag
Downstream sequence
ctcagaaaataaataacttgtcatgtagtcaaaatgtagaaaatctagattcacatccagaccttcttcctcagaagttcatgtatttccactctctaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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