Basic Information
VIS ID
TVIS10008094
Fusion event
HBV-LOC649133 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
120133276/120262567 (Hg38)
End
120133276/120262567 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA11B
Target gene
LOC649133
Nearest miRNA
hsa-mir-10392/Upstream/949555; hsa-let-7a-2/Downstream/1837190;
Nearest TSS
ENST00000527297/Upstream/22306; ENST00000606153/Downstream/3365;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22388, chr11-CpG: 68/Downstream/62529
Upstream sequence
attacaggcattataacatttcagtcctaaataagggaatatgcatctctaaaacatgaagacattttccttcttaagcacaatatcattatcacacaaa
Downstream sequence
acaaaacgaatccctcaTTTAATTCTCACAGCAATTTTGATGGTAAAGTATCTTAAAATATGCACACGCATTTTTAATTGCTTTATGTATCAGCTATGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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