Basic Information
VIS ID
TVIS10008096
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
+
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr11
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
23514246/23492700 (Hg38)
End
23514246/23492700 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/73510; hsa-let-7a-2/Downstream/4022270;
Nearest TSS
ENST00000527297/Upstream/327513; ENST00000534068/Downstream/237888;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/86897, chr11-CpG: 34/Downstream/237707
Nearby gene
CCDC179(-632274) ; LUZP2(+1004270) ;
Upstream sequence
ggctaagacctccagtaGTGAGGGAGAGAAAAAGTCCCACATATTGAGCCTAGAAAGTAATTCTAGAATCTGCTCCGGGAGGTTGGGGGGAAGCAGATGA
Downstream sequence
ATAATAAAGTTCTGCAACAGAAGTTTTTAGAAATTTCAGAGGTATTAATTAGAACCTTGACTCTAGTCTTTTCAAAGTCTGAGAAATGGCAATGAGGGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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