PRB2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008103
Fusion event
HBV-PRB2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11545463/11392529 (Hg38)
End
11545463/11392529 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRB2
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/2152978; hsa-let-7i/Downstream/719423;
Nearest TSS
ENST00000382841/Upstream/36938; ENST00000545239/Downstream/3036;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/220797, chr12-CpG: 49/Downstream/107769
Upstream sequence
CTCAAGAGGCTGGTGTGAGGCAGGACTGAGCAAACAGTGCTCAGGTGAAAACTTTAAATGGGAGGTCTCTCAGTTTGTGCACAGAAAACAGAGCGCCAGA
Downstream sequence
GAGAACATGGTACTACTTCCTTGTTGCCAACACAACTTAAGACAGATTATTTGGAATTTTGTTTCTcaacatcagaattccttaaagagtttgttacaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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