VISDB Viral Integration Site DataBase

VIS ID

TVIS10008104

Fusion event

HBV-SLCO1B3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1796

Orient

-

Integrated sequence

CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT

Chromosome

chr12

Cytoband

p12.2

Reference genome

Start

End

21063762/20910828 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-6867-3p ; hsa-mir-188-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-532-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4639-3p ; hsa-mir-4457 ; hsa-mir-3936 ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-190a-3p ; hsa-mir-340-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/3237434; hsa-let-7i/Downstream/3301593;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/357758, chr12-CpG: 34/Downstream/526707

Upstream sequence

aatgtatttttaatttcaaattccacttgttcattgctgatttataggaaaacttttcactttggcatattaatcttatatcctgcaaacttgttataac

Downstream sequence

tgcttattagttccagtagtgtttttgtctattatttgagattttctacatatacatatgcaaacaaaggtagttttattccttcctttcaatctgtata