Basic Information
VIS ID
TVIS10008106
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2197
Orient
+
Integrated sequence
ATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGC| |AACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTA
Host Sequence
Chromosome
chr12
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
98225448/97831670 (Hg38)
End
98225448/97831670 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/267759; hsa-mir-1178/Downstream/107386;
Nearest TSS
ENST00000382841/Upstream/555461; ENST00000548911/Downstream/460775;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/924161, chr12-CpG: 31/Downstream/625242
Nearby gene
MIR135A2(-267759) ; MIR4303(+163713) ;
Nearest cancer related gene
MIR135A2(TSG, -267759) ;
Upstream sequence
aaggatatccaggaattgaactcagctctgcaccaagcggacctaatagaaatctacagaactctccagcccaaattaacagaatatacattcttctcag
Downstream sequence
taccacactgcacttattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaagagacattgtaacaaactgtctttcaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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