Basic Information
VIS ID
TVIS10008112
Fusion event
HBV-LOC107984701 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1845
Orient
+
Integrated sequence
GGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATC| |TCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGT
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
49990208/49523490 (Hg38)
End
49990208/49523490 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107984701
Nearest miRNA
hsa-mir-208a/Upstream/1762386; hsa-mir-1185-1/Downstream/442909;
Nearest TSS
ENST00000550708/Upstream/445985; ENST00000557531/Downstream/62835;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1847104, chr14-CpG: 30/Downstream/62442
Nearby gene
LINC00648(-1725991) ; RPS29(+53834) ;
Upstream sequence
ATTTAGCAACGTGTACCAGCTTCCTCCCTCTTCTGCATTGCCCTCTGCAGCTCTCCATGGGTGTTCCAGTGAGAGCCCCCTACTCCTCCCCACTGCCCAG
Downstream sequence
GATCCCTGCTGAGTACAGGAAAATAGTCAAAACTATGACAGAGGAGATAAGGCTACCAGATCAAAGGGTTCAGGACAAGAGACGAGTGTAAATTAAGGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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