Basic Information
VIS ID
TVIS10008116
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
66847302/66380584 (Hg38)
End
66847302/66380584 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA14B
Nearest miRNA
hsa-mir-208a/Upstream/909398; hsa-mir-1185-1/Downstream/1061271;
Nearest TSS
ENST00000550708/Upstream/268949; ENST00000450299/Downstream/31120;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/366660, chr14-CpG: 159/Downstream/127067
Nearby gene
FUT8(-636463) ; OLMALINC(+105807) ;
Upstream sequence
CCAGAGAATAGATGCTATTATCTTCAGTTTCTCCCTACCTCATTTCAAGGATTTAGTCCTTGACTTTCAAATTCTCCTCCCCCACAATTCTTTTAAACAT
Downstream sequence
TCACGAACTGATTCACTTGTATTGTGCTTTTGCATTTTGAGACCTATTATCTTTTGTTCCAACTGTGTAATAAGTTTTTTTGCCAAAACAcagtgaaagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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