VISDB Viral Integration Site DataBase

VIS ID

TVIS10008117

Fusion event

HBV-OIP5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1823

Orient

-

Integrated sequence

TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA

Chromosome

chr15

Cytoband

q15.1

Reference genome

Start

End

41600776/41308578 (Hg38)

Orient

-

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-29c-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-7977 ; hsa-mir-621 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-4480 ; hsa-mir-4648 ; hsa-mir-4727-3p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-1296-3p ; hsa-mir-578 ; hsa-mir-218-5p ; hsa-mir-449c-3p ; hsa-mir-526b-5p ; hsa-mir-8086 ; hsa-mir-4445-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-219a-5p ; hsa-mir-508-3p ; hsa-mir-6080 ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-371a-3p ; hsa-mir-371b-3p ; hsa-mir-6787-3p ; hsa-mir-767-5p ; hsa-mir-5690 ; hsa-mir-6865-3p ; hsa-mir-6504-3p ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-4775 ; hsa-mir-5580-3p ; hsa-mir-590-3p ; hsa-mir-139-5p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-1233-1/Upstream/4335677; hsa-mir-10393/Downstream/383007;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/24240, chr15-CpG: 82/Downstream/23586

Upstream sequence

AAAGTAAATTTGATTAGGCAGGCCTTCTTTTAAGGACCTCATAAAGGtcatccctccatcaccttattaattcctattcgtctttcagaccaccgctgaa

Downstream sequence

acttcacttctacacagaggctttctttcccagaaacccagaccaggtcagttacctgctttatgtgcgtgtatccctatgttcctttacttcaaaaccc