Basic Information
VIS ID
TVIS10008123
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
76667308/76633411 (Hg38)
End
76667308/76633411 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/6602989; hsa-mir-11401/Downstream/235525;
Nearest TSS
ENST00000527434/Upstream/50855; ENST00000512279/Downstream/1587;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/398116, chr16-CpG: 34/Downstream/1527
Nearby gene
CNTNAP4(-74173) ; MIR4719(+235525) ;
Upstream sequence
cacggtggcaggcgcctgtagtcctagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggcggagcttacagtgagctgagatcgcgcc
Downstream sequence
actgcactcgagcctgggcgacagagcgagactccgtctcaaaaacaaaaacaaaaaaGTTTAATGATGAGTAGGTACAGAAAATAAATGTACAAAATGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate