Basic Information
VIS ID
TVIS10008125
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2334
Orient
+
Integrated sequence
AAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCG| |GAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAAT
Host Sequence
Chromosome
chr17
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
25617470/27290444 (Hg38)
End
25617470/27290444 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/7945870; hsa-mir-10226/Downstream/3466;
Nearest TSS
ENST00000595228/Upstream/48783; ENST00000583786/Downstream/3632;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/308171, chr17-CpG: 67/Downstream/3529
Nearby gene
MIR4522(+3466) ;
Upstream sequence
tggacatttcactagagtaggaaatacaaaagatggagcagactgaggagaaatgatgtgttcagttttgacattttgagttttattgtaagcatttgaa
Downstream sequence
catgtaaattttaaacttaagacaggccgggctcagtggctcatgcctgtaatcccggcactttgggaagccgacacaggtggatcacctgaggtcagga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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