Basic Information
VIS ID
TVIS10008129
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
63406007/65409889 (Hg38)
End
63406007/65409889 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/587787; hsa-mir-1250/Downstream/1377183;
Nearest TSS
ENST00000595228/Upstream/221185; ENST00000579474/Downstream/47652;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/286301, chr17-CpG: 66/Downstream/126948
Nearby gene
RGS9(-182186) ; AXIN2(+118676) ;
Nearest cancer related gene
AXIN2(TSG, +118676) ;
Upstream sequence
agacatacaaatggccaacaggtatataaaaatgctcaatactactaatcatcagggacatgcatatcaaaaccataatgagatatcatcttaccccagt
Downstream sequence
tagaatggctattataaaaaaagacaaaaaataataaatgctggtgaggattcagagaaagggaaacactcgtgcattgttggtggaaatgtgaattggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate