ZBTB7C _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008132
Fusion event
HBV-ZBTB7C integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1754
Orient
-
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45788896/48262525 (Hg38)
End
45788896/48262525 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/881960; hsa-mir-122/Downstream/408075;
Nearest TSS
ENST00000575820/Upstream/58924; ENST00000591412/Downstream/75866;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/100384, chr18-CpG: 262/Downstream/145557
Nearby gene
ZBTB7C(-125216) ; CTIF(+276531) ;
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
CTATCCTCAGAGAGCTTGCTGTCTCACTAAGGAGATGAGGCCTACCCACAAGAAACTCTCTAAGACAAACACCAGGCAGTATATGAAACCAGGGCTCATA
Downstream sequence
TAGATGATGTGGAAATGCTCAGAAAACAGCACCAGTGTAGAGTGGTCTCATCTTGGAGTAAGCCCTACAGACTTACTTTATAAATAAGGAAATCATCAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate