VISDB Viral Integration Site DataBase

VIS ID

TVIS10008138

Fusion event

HBV-KCNJ3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1925

Orient

+

Integrated sequence

TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA| |ATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCC

Chromosome

chr2

Cytoband

q24.1

Reference genome

Start

End

155711744/154855232 (Hg38)

Orient

-

Location type

Exonic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-1277-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-374a-3p ; hsa-mir-6867-5p ; hsa-mir-2115-3p ; hsa-mir-361-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-129-5p ; hsa-mir-1273f ; hsa-mir-143-3p ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-6088

Nearest miRNA

hsa-mir-128-1/Upstream/3486821; hsa-mir-10b/Downstream/4331603;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/155675, chr2-CpG: 82/Downstream/1464507

Upstream sequence

AGTTCCGGGCAACTCAGAAGAAAAACTGGTATCTAAAACCACCAAGATGTTATCTGATCCCATGAGCCAGTCTGTGGCTGATTTGCCACCAAAGCTTCAA

Downstream sequence

AAGATGGCTGGAGGAGCAGCTAGGATGGAAGGGAACCTTCCAGCCAAATTAAGAAAAATGAACTCTGATCGCTTCACATAACAAAGCACTCCCTTAGGCA