VISDB Viral Integration Site DataBase

VIS ID

TVIS10008140

Fusion event

HBV-CDH4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1797

Orient

-

Integrated sequence

TTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATT| |GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT

Chromosome

chr20

Cytoband

q13.33

Reference genome

Start

End

59956805/61381749 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-7111-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6832-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-570-3p

Nearest miRNA

hsa-mir-103a-2/Upstream/817124; hsa-mir-1-1/Downstream/571797;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/91736, chr20-CpG: 16/Downstream/8771

Nearest cancer related gene

CDH4(TSG, No orient, 0)

Upstream sequence

TTTGAGCCACCAGTTAACCCCCCCACCTAAGGAATATCAATTACTCACTTTCCCACCCCAATTTGGCCTTTGCATAATCTACTACCAGAGAAACACTTTG

Downstream sequence

ATCACATGACACCTTTCAGAAAACTATTTAAAAAGATAACTGTTggccaggtgtagtggctcacacctgtaatcctagcactttgagaagctgggcgggt