Basic Information
VIS ID
TVIS10008143
Fusion event
HBV-LOC284930 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1632
Orient
-
Integrated sequence
TCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCA| |CCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGAC
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
48187172/47791423 (Hg38)
End
48187172/47791423 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
LOC284930
Nearest miRNA
hsa-let-7a-3/Upstream/1677655; hsa-mir-12114/Downstream/482941;
Nearest TSS
ENST00000624155/Upstream/105182; ENST00000449941/Downstream/69248;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/577851, chr22-CpG: 25/Downstream/417922
Nearby gene
MIR3201(+483004) ;
Upstream sequence
atgcaaacatggtaaaaatataataaattgaattcaggactatgtaaaatttatatacatgtgtatgaatatatataattatatatatgaatatataatt
Downstream sequence
atatatattagtatttattccaagtttattttatgcaatgagtttataacattaggaaaaatccattaatataattgatcatattaagaaattaagaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate